Heterologous Prime-Boost Regimens with a Recombinant Chimpanzee Adenoviral Vector and Adjuvanted F4 Protein Elicit Polyfunctional HIV-1-Specific T-Cell Responses in Macaques

HIV-1-specific CD4(+) and CD8(+) T lymphocytes are important for HIV-1 replication control. F4/AS01 consists of F4 recombinant fusion protein (containing clade B Gag/p24, Pol/RT, Nef and Gag/p17) formulated in AS01 Adjuvant System, and was shown to induce F4-specific polyfunctional CD4(+) T-cell res...

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Pubblicato in:PLoS One
Autori principali: Lorin, Clarisse, Vanloubbeeck, Yannick, Baudart, Sébastien, Ska, Michaël, Bayat, Babak, Brauers, Geoffroy, Clarinval, Géraldine, Donner, Marie-Noëlle, Marchand, Martine, Koutsoukos, Marguerite, Mettens, Pascal, Cohen, Joe, Voss, Gerald
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391709/
https://ncbi.nlm.nih.gov/pubmed/25856308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122835
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