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Evaluation of biological safety in vitro and immunogenicity in vivo of recombinant Escherichia coli Shiga toxoids as candidate vaccines in cattle

Cattle are the most important reservoir for enterohemorrhagic Escherichia coli (EHEC), a subset of shigatoxigenic E. coli (STEC) capable of causing life-threatening infectious diseases in humans. In cattle, Shiga toxins (Stx) suppress the immune system thereby promoting long-term STEC shedding. Firs...

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Detalhes bibliográficos
Publicado no:Vet Res
Main Authors: Kerner, Katharina, Bridger, Philip S, Köpf, Gabriele, Fröhlich, Julia, Barth, Stefanie, Willems, Hermann, Bauerfeind, Rolf, Baljer, Georg, Menge, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391668/
https://ncbi.nlm.nih.gov/pubmed/25889651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13567-015-0175-2
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