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Application of Long-Acting VLHL PAI-1 during Sutureless Partial Nephrectomy in Mice Reduces Bleeding

PAI-1 prevents lysis of blood clot by inhibiting the urokinase and tPA induced conversion of plasminogen to plasmin. VLHL PAI-1 protein mutant was created to extend half-life over 700 hours. The objective of this paper was to test VLHL PAI-1 effects on bleeding during partial nephrectomy in mice. Al...

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Detalles Bibliográficos
Publicado en:Biomed Res Int
Main Authors: Shahrour, Khaled, Keck, Rick, Jankun, Jerzy
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391615/
https://ncbi.nlm.nih.gov/pubmed/25883959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/392862
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