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Relative performance of gene- and pathway-level methods as secondary analyses for genome-wide association studies

BACKGROUND: Despite the success of genome-wide association studies (GWAS), there still remains “missing heritability” for many traits. One contributing factor may be the result of examining one marker at a time as opposed to a group of markers that are biologically meaningful in aggregate. To addres...

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Vydáno v:BMC Genet
Hlavní autoři: Wojcik, Genevieve L, Kao, WH Linda, Duggal, Priya
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391470/
https://ncbi.nlm.nih.gov/pubmed/25887572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12863-015-0191-2
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