Lgr5+ Cells Regenerate Hair Cells via Proliferation and Direct Transdifferentiation in Damaged Neonatal Mouse Utricle

Recruitment of endogenous progenitors is critical during tissue repair. The inner ear utricle requires mechanosensory hair cells (HCs) to detect linear acceleration. After damage, non-mammalian utricles regenerate HCs via both proliferation and direct transdifferentiation. In adult mammals, limited...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Wang, Tian, Chai, Renjie, Kim, Grace S., Pham, Nicole, Jansson, Lina, Nguyen, Duc-Huy, Kuo, Bryan, May, Lindsey, Zuo, Jian, Cunningham, Lisa L., Cheng, Alan G.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391285/
https://ncbi.nlm.nih.gov/pubmed/25849379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7613
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