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Organotypic vibrosections from whole brain adult Alzheimer mice (overexpressing amyloid-precursor-protein with the Swedish-Dutch-Iowa mutations) as a model to study clearance of beta-amyloid plaques

Alzheimer's disease is a severe neurodegenerative disorder of the brain, pathologically characterized by extracellular beta-amyloid plaques, intraneuronal Tau inclusions, inflammation, reactive glial cells, vascular pathology and neuronal cell death. The degradation and clearance of beta-amyloi...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Autor principal: Humpel, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391240/
https://ncbi.nlm.nih.gov/pubmed/25914642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2015.00047
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