Protective Role of PGC-1α in Diabetic Nephropathy Is Associated with the Inhibition of ROS through Mitochondrial Dynamic Remodeling

The overproduction of mitochondrial reactive oxygen species (ROS) plays a key role in the pathogenesis of diabetic nephropathy (DN). However, the underlying molecular mechanism remains unclear. Our aim was to investigate the role of PGC-1α in the pathogenesis of DN. Rat glomerular mesangial cells (R...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Guo, Kaifeng, Lu, Junxi, Huang, Yan, Wu, Mian, Zhang, Lei, Yu, Haoyong, Zhang, Mingliang, Bao, Yuqian, He, John Cijiang, Chen, Haibing, Jia, Weiping
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4390193/
https://ncbi.nlm.nih.gov/pubmed/25853493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125176
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