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Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells

LyP-1 is a peptide selected from a phage-displayed peptide library that specifically binds to tumor and endothelial cells of tumor lymphatics in certain tumors. Fluorescein-conjugated LyP-1 and a related peptide, LyP-1b, strongly accumulated in primary MDA-MB-435 breast cancer xenografts and their m...

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Autores principales: Laakkonen, Pirjo, Åkerman, Maria E., Biliran, Hector, Yang, Meng, Ferrer, Fernando, Karpanen, Terhi, Hoffman, Robert M., Ruoslahti, Erkki
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2004
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC438985/
https://ncbi.nlm.nih.gov/pubmed/15197262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403317101
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