Design and Evaluation of Thioalkylated Mannose-Modified Dendrimer (G3)/α-Cyclodextrin Conjugates as Antigen-Presenting Cell-Selective siRNA Carriers

To design and evaluate the potential use of thioalkylated mannose-modified dendrimer (generation 3; G3) conjugates with α-cyclodextrin (Man-S-α-CDE (G3)) as novel antigen-presenting cell (APC)-selective siRNA carriers, we investigated the RNAi effects of siRNA complexes with Man-S-α-CDEs (G3). Man-S...

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Bibliographic Details
Published in:AAPS J
Main Authors: Motoyama, Keiichi, Mitsuyasu, Ryosuke, Akao, Chiho, Tanaka, Takahiro, Ohyama, Ayumu, Sato, Nana, Higashi, Taishi, Arima, Hidetoshi
Format: Artigo
Language:Inglês
Published: Springer US 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4389755/
https://ncbi.nlm.nih.gov/pubmed/25236864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9665-9
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