A Semi-mechanistic Model for the Effects of a Novel Glucagon Receptor Antagonist on Glucagon and the Interaction Between Glucose, Glucagon, and Insulin Applied to Adaptive Phase II Design

A potent novel compound (MK-3577) was developed for the treatment of type 2 diabetes mellitus (T2DM) through blocking the glucagon receptor. A semi-mechanistic model was developed to describe the drug effect on glucagon and the interaction between glucagon, insulin, and glucose in healthy subjects (...

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Veröffentlicht in:AAPS J
Hauptverfasser: Peng, Joanna Z., Denney, William S., Musser, Bret J., Liu, Rong, Tsai, Kuenhi, Fang, Lanyan, Reitman, Marc L., Troyer, Matthew D., Engel, Samuel S., Xu, Lei, Stoch, Aubrey, Stone, Julie A., Kowalski, Ken G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4389739/
https://ncbi.nlm.nih.gov/pubmed/25160589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9648-x
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