A Semi-mechanistic Model for the Effects of a Novel Glucagon Receptor Antagonist on Glucagon and the Interaction Between Glucose, Glucagon, and Insulin Applied to Adaptive Phase II Design

A potent novel compound (MK-3577) was developed for the treatment of type 2 diabetes mellitus (T2DM) through blocking the glucagon receptor. A semi-mechanistic model was developed to describe the drug effect on glucagon and the interaction between glucagon, insulin, and glucose in healthy subjects (...

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Detalhes bibliográficos
Publicado no:AAPS J
Main Authors: Peng, Joanna Z., Denney, William S., Musser, Bret J., Liu, Rong, Tsai, Kuenhi, Fang, Lanyan, Reitman, Marc L., Troyer, Matthew D., Engel, Samuel S., Xu, Lei, Stoch, Aubrey, Stone, Julie A., Kowalski, Ken G.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4389739/
https://ncbi.nlm.nih.gov/pubmed/25160589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9648-x
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