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Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex
Association of two proteins can be described as a two-step process, with the formation of an encounter complex followed by desolvation and establishment of a tight complex. Here, by using the computer algorithm pare, we designed a set of mutants of the Ras effector protein Ral guanine nucleotide dis...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC438957/ https://ncbi.nlm.nih.gov/pubmed/15197281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401160101 |
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