Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788.

We describe the characteristics of a potent and selective endothelin (ET) B-receptor antagonist, BQ-788 [N-cis-2,6-dimethylpiperidinocarbonyl-L-gamma-methylleucyl-D -1- methoxycarbonyltryptophanyl-D-norleucine]. In vitro, this compound potently and competitively inhibits 125I-labeled endothelin 1 (E...

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Detalhes bibliográficos
Main Authors: Ishikawa, K, Ihara, M, Noguchi, K, Mase, T, Mino, N, Saeki, T, Fukuroda, T, Fukami, T, Ozaki, S, Nagase, T
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC43895/
https://ncbi.nlm.nih.gov/pubmed/8197152
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