Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not.

Analysis of the three-dimensional structure of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) complexed with double-stranded DNA indicates that while many nucleoside-resistance mutations are not at the putative dNTP binding site, several are in positions to interact with the...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Boyer, P L, Tantillo, C, Jacobo-Molina, A, Nanni, R G, Ding, J, Arnold, E, Hughes, S H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43893/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7515182/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.11.4882
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