Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA

p53 binds enhancers to regulate key target genes. Here, we globally mapped p53-regulated enhancers by looking at enhancer RNA (eRNA) production. Intriguingly, while many p53-induced enhancers contained p53-binding sites, most did not. As long non-coding RNAs (lncRNAs) are prominent regulators of chr...

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Publicado no:Nat Commun
Main Authors: Léveillé, Nicolas, Melo, Carlos A., Rooijers, Koos, Díaz-Lagares, Angel, Melo, Sonia A., Korkmaz, Gozde, Lopes, Rui, Moqadam, Farhad Akbari, Maia, Ana R., Wijchers, Patrick J., Geeven, Geert, den Boer, Monique L., Kalluri, Raghu, de Laat, Wouter, Esteller, Manel, Agami, Reuven
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4389233/
https://ncbi.nlm.nih.gov/pubmed/25813522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7520
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