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Small Molecule Ice Recrystallization Inhibitors Enable Freezing of Human Red Blood Cells with Reduced Glycerol Concentrations

In North America, red blood cells (RBCs) are cryopreserved in a clinical setting using high glycerol concentrations (40% w/v) with slow cooling rates (~1°C/min) prior to storage at −80°C, while European protocols use reduced glycerol concentrations with rapid freezing rates. After thawing and prior...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Capicciotti, Chantelle J., Kurach, Jayme D. R., Turner, Tracey R., Mancini, Ross S., Acker, Jason P., Ben, Robert N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4389209/
https://ncbi.nlm.nih.gov/pubmed/25851700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09692
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