DSCAM Promotes Refinement in the Mouse Retina through Cell Death and Restriction of Exploring Dendrites

In this study we develop and use a gain-of-function mouse allele of the Down syndrome cell adhesion molecule (Dscam) to complement loss-of-function models. We assay the role of Dscam in promoting cell death, spacing, and laminar targeting of neurons in the developing mouse retina. We find that ectop...

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Pubblicato in:J Neurosci
Autori principali: Li, Shuai, Sukeena, Joshua M., Simmons, Aaron B., Hansen, Ethan J., Nuhn, Renee E., Samuels, Ivy S., Fuerst, Peter G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388924/
https://ncbi.nlm.nih.gov/pubmed/25855178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2202-14.2015
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