FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 expression

FOXO transcription factors are considered bona fide tumor suppressors; however, recent studies showed FOXOs are also required for tumor survival. Here, we identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:EMBO Rep
Autori principali: Charitou, Paraskevi, Rodriguez-Colman, Maria, Gerrits, Johan, van Triest, Miranda, Groot Koerkamp, Marian, Hornsveld, Marten, Holstege, Frank, Verhoeven-Duif, Nanda M, Burgering, Boudewijn MT
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2015
Soggetti:
Scientific Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388612/
https://ncbi.nlm.nih.gov/pubmed/25648147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439096
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi