Potential Role of Notch Signalling in CD34(+) Chronic Myeloid Leukaemia Cells: Cross-Talk between Notch and BCR-ABL

Notch signalling is critical for haemopoietic stem cell (HSC) self-renewal and survival. The role of Notch signalling has been reported recently in chronic myeloid leukaemia (CML) – a stem cell disease characterized by BCR-ABL tyrosine kinase activation. Therefore, we studied the relationship betwee...

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Bibliographic Details
Published in:PLoS One
Main Authors: Aljedai, Abdullah, Buckle, Anne-Marie, Hiwarkar, Prashant, Syed, Farhatullah
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388554/
https://ncbi.nlm.nih.gov/pubmed/25849484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123016
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