Patient-derived Models of Acquired Resistance Can Identify Effective Drug Combinations for Cancer

Targeted cancer therapies have produced substantial clinical responses but most tumors develop resistance to these drugs. Here we describe a pharmacogenomic platform that facilitates rapid discovery of drug combinations that can overcome resistance. We established cell culture models derived from bi...

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Wydane w:Science
Główni autorzy: Crystal, Adam S., Shaw, Alice T., Sequist, Lecia V., Friboulet, Luc, Niederst, Matthew J., Lockerman, Elizabeth L., Frias, Rosa L., Gainor, Justin F., Amzallag, Arnaud, Greninger, Patricia, Lee, Dana, Kalsy, Anuj, Gomez-Caraballo, Maria, Elamine, Leila, Howe, Emily, Hur, Wooyoung, Lifshits, Eugene, Robinson, Hayley E., Katayama, Ryohei, Faber, Anthony C., Awad, Mark M., Ramaswamy, Sridhar, Mino-Kenudson, Mari, Iafrate, A. John, Benes, Cyril H., Engelman, Jeffrey A.
Format: Artigo
Język:Inglês
Wydane: 2014
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388482/
https://ncbi.nlm.nih.gov/pubmed/25394791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1254721
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