Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition

10-Formyltetrahydrofolate dehydrogenase (FDH), which is composed of a small N-terminal domain (Nt-FDH) and a large C-terminal domain, is an abundant folate enzyme in the liver and converts 10-formyltetrahydrofolate (10-FTHF) to tetrahydrofolate (THF) and CO(2). Nt-FDH alone possesses a hydrolase act...

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Bibliografiske detaljer
Udgivet i:Acta Crystallogr D Biol Crystallogr
Main Authors: Lin, Chien-Chih, Chuankhayan, Phimonphan, Chang, Wen-Ni, Kao, Tseng-Ting, Guan, Hong-Hsiang, Fun, Hoong-Kun, Nakagawa, Atsushi, Fu, Tzu-Fun, Chen, Chun-Jung
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2015
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388273/
https://ncbi.nlm.nih.gov/pubmed/25849409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004715002928
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