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The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy

Structural analysis of protein fibrillation is inherently challenging. Given the crucial role of fibrils in amyloid diseases, method advancement is urgently needed. A hybrid modelling approach is presented enabling detailed analysis of a highly ordered and hierarchically organized fibril of the GNNQ...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr D Biol Crystallogr
Main Authors: Langkilde, Annette E., Morris, Kyle L., Serpell, Louise C., Svergun, Dmitri I., Vestergaard, Bente
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388266/
https://ncbi.nlm.nih.gov/pubmed/25849399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004715001674
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