Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalamia in humans and mice

Angle-closure glaucoma (ACG) is a subset of glaucoma affecting 16 million people(1–3). Although 4 million people are bilaterally blind from ACG(4,5), the causative molecular mechanisms of ACG remain to be defined. High intraocular pressure induces glaucoma in ACG. High intraocular pressure tradition...

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Vydáno v:Nat Genet
Hlavní autoři: Nair, K Saidas, Hmani-Aifa, Mounira, Ali, Zain, Kearney, Alison L, Salem, Salma Ben, Macalinao, Danilo G, Cosma, Ioan M, Bouassida, Walid, Hakim, Bochra, Benzina, Zeineb, Soto, Ileana, Söderkvist, Peter, Howell, Gareth R, Smith, Richard S, Ayadi, Hammadi, John, Simon W M
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388060/
https://ncbi.nlm.nih.gov/pubmed/21532570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.813
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