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Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery from liver injury

BACKGROUND & AIMS: Foxl1(+) hepatic progenitor cells (HPCs) differentiate into cholangiocytes and hepatocytes following liver injury. We investigated the requirement for Foxl1+ HPCs in recovery from liver injury in mice. METHODS: We developed mice in which we can trace and delete Foxl1-expressin...

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Bibliographic Details
Published in:Gastroenterology
Main Authors: Shin, Soona, Upadhyay, Naman, Greenbaum, Linda E., Kaestner, Klaus H.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387775/
https://ncbi.nlm.nih.gov/pubmed/25286440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.09.039
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