Multifunctional mitoxantrone-conjugated magnetic nanosystem for targeted therapy of folate receptor-overexpressing malignant cells

BACKGROUND: Targeted delivery of anticancer chemotherapeutics such as mitoxantrone (MTX) can significantly intensify their cytotoxic effects selectively in solid tumors such as breast cancer. In the current study, folic acid (FA)-armed and MTX-conjugated magnetic nanoparticles (MNPs) were engineered...

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Detalhes bibliográficos
Publicado no:J Nanobiotechnology
Main Authors: Barar, Jaleh, Kafil, Vala, Majd, Mostafa Heidari, Barzegari, Abolfazl, Khani, Sajjad, Johari-Ahar, Mohammad, Asgari, Davoud, Cokous, George, Omidi, Yadollah
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387580/
https://ncbi.nlm.nih.gov/pubmed/25880772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12951-015-0083-7
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