2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice

AIM: Sterol-regulatory element binding proteins (SREBPs) are major transcription factors that regulate liver lipid biosynthesis. In this article we reported a novel synthetic compound 2-(3-benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (ZJ001) that inhibited the SREBP-1c pa...

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Publicado en:Acta Pharmacol Sin
Autores principales: Zhang, Jin, Zhang, Li-na, Chen, Dong-mei, Fu, Yan-yun, Zhang, Feng, Yang, Ling-ling, Xia, Chun-mei, Jiang, Hao-wen, Tang, Chun-lan, Xie, Zhi-fu, Yang, Fan, Li, Jia, Tang, Jie, Li, Jing-ya
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387297/
https://ncbi.nlm.nih.gov/pubmed/25832429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.149
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