Fission Yeast Cdk7 Controls Gene Expression through both Its CAK and C-Terminal Domain Kinase Activities

Cyclin-dependent kinase (Cdk) activation and RNA polymerase II transcription are linked by the Cdk7 kinase, which phosphorylates Cdks as a trimeric Cdk-activating kinase (CAK) complex, and serine 5 within the polymerase II (Pol II) C-terminal domain (CTD) as transcription factor TFIIH-bound CAK. How...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Devos, Maxime, Mommaerts, Elise, Migeot, Valerie, van Bakel, Harm, Hermand, Damien
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387208/
https://ncbi.nlm.nih.gov/pubmed/25691663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00024-15
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