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Nucleotide exchange in dimeric MCAK induces longitudinal and lateral stress at microtubule ends to support depolymerization

Members of the kinesin-13 sub-family use their motor domains in an unconventional fashion to initiate microtubule depolymerization at microtubule (MT) ends, suggesting unique conformational transitions for lattice engagement, end adaptation or both. Using hydrogen/deuterium exchange and electron mic...

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書目詳細資料
發表在:Structure
Main Authors: Burns, Kyle M., Wagenbach, Mike, Wordeman, Linda, Schriemer, David C.
格式: Artigo
語言:Inglês
出版: 2014
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386277/
https://ncbi.nlm.nih.gov/pubmed/25066134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.06.010
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