APOE ε4 moderates abnormal CSF-abeta-42 levels, while neurocognitive impairment is associated with abnormal CSF tau levels in HIV+ individuals – a cross-sectional observational study

BACKGROUND: Cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau and p-tau have a characteristic pattern in Alzheimer’s Disease (AD). Their roles in HIV-associated neurocognitive disorder (HAND) remains unclear. METHODS: Adults with chronic treated HIV disease were recruited (n = 43, aged 56.7 ± 7.9;...

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發表在:BMC Neurol
Main Authors: Cysique, Lucette A, Hewitt, Timothy, Croitoru-Lamoury, Juliana, Taddei, Kevin, Martins, Ralph N, Chew, Constance SN, Davies, Nicholas NWS, Price, Patricia, Brew, Bruce J
格式: Artigo
語言:Inglês
出版: BioMed Central 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386081/
https://ncbi.nlm.nih.gov/pubmed/25880550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12883-015-0298-0
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