Prevention of pulmonary hypoplasia and pulmonary vascular remodeling by antenatal simvastatin treatment in nitrofen-induced congenital diaphragmatic hernia

Congenital diaphragmatic hernia (CDH) has a high mortality rate mainly due to lung hypoplasia and persistent pulmonary hypertension of the newborn (PPHN). Simvastatin has been shown to prevent the development of pulmonary hypertension (PH) in experimental models of PH. We, therefore, hypothesized th...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Makanga, Martine, Maruyama, Hidekazu, Dewachter, Celine, Da Costa, Agnès Mendes, Hupkens, Emeline, de Medina, Geoffrey, Naeije, Robert, Dewachter, Laurence
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385987/
https://ncbi.nlm.nih.gov/pubmed/25617377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00345.2014
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