Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer

The Kruppel-like transcription factors (KLFs) 4 and 5 (KLF4/5) are coexpressed in mouse embryonic stem cells, where they function redundantly to maintain pluripotency. In mammary carcinoma, KLF4/5 can each impact the malignant phenotype, but potential linkages to drug resistance remain unclear. In p...

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Udgivet i:Cell Death Dis
Main Authors: Farrugia, M K, Sharma, S B, Lin, C-C, McLaughlin, S L, Vanderbilt, D B, Ammer, A G, Salkeni, M A, Stoilov, P, Agazie, Y M, Creighton, C J, Ruppert, J M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385942/
https://ncbi.nlm.nih.gov/pubmed/25789974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.65
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