DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance

Though metastatic cancers often initially respond to genotoxic therapeutics, acquired resistance is common. In addition to cytotoxic effects on tumor cells, DNA damaging agents such as ionizing radiation and chemotherapy induce injury in benign cells of the tumor microenvironment resulting in the pr...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Huber, Roland M., Lucas, Jared M., Gomez-Sarosi, Luis A., Coleman, Ilsa, Zhao, Song, Coleman, Roger, Nelson, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385841/
https://ncbi.nlm.nih.gov/pubmed/25575823
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