Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST)

Background: c-Kit/α-PDGFR targeted therapies are effective for gastrointestinal stromal tumors (GIST), but, >50% develop drug resistance. Methods: RTK expression (c-Kit, c-Met, AXL, HER-1, HER-2, IGF-1R) in pre-/post-imatinib (IM) GIST patient samples (n=16) and 4 GIST cell lines were examined fo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Mahadevan, Daruka, Theiss, Noah, Morales, Carla, Stejskal, Amy E., Cooke, Laurence S., Zhu, Min, Kurtzman, Drew, Swart, Rachel, Ong, Evan, Qi, Wenqing
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385828/
https://ncbi.nlm.nih.gov/pubmed/25557174
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