Blockade of the JNK Signalling as a Rational Therapeutic Approach to Modulate the Early and Late Steps of the Inflammatory Cascade in Polymicrobial Sepsis

Cecal ligation and puncture (CLP) is an experimental polymicrobial sepsis induced systemic inflammation that leads to acute organ failure. Aim of our study was to evaluate the effects of SP600125, a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, to modulate the early and late steps of the inf...

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Dades bibliogràfiques
Publicat a:Mediators Inflamm
Autors principals: Pizzino, Gabriele, Bitto, Alessandra, Pallio, Giovanni, Irrera, Natasha, Galfo, Federica, Interdonato, Monica, Mecchio, Anna, De Luca, Filippo, Minutoli, Letteria, Squadrito, Francesco, Altavilla, Domenica
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385695/
https://ncbi.nlm.nih.gov/pubmed/25873765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/591572
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