Blockade of the JNK Signalling as a Rational Therapeutic Approach to Modulate the Early and Late Steps of the Inflammatory Cascade in Polymicrobial Sepsis

Cecal ligation and puncture (CLP) is an experimental polymicrobial sepsis induced systemic inflammation that leads to acute organ failure. Aim of our study was to evaluate the effects of SP600125, a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, to modulate the early and late steps of the inf...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Mediators Inflamm
Hlavní autoři: Pizzino, Gabriele, Bitto, Alessandra, Pallio, Giovanni, Irrera, Natasha, Galfo, Federica, Interdonato, Monica, Mecchio, Anna, De Luca, Filippo, Minutoli, Letteria, Squadrito, Francesco, Altavilla, Domenica
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385695/
https://ncbi.nlm.nih.gov/pubmed/25873765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/591572
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky