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Blockade of the JNK Signalling as a Rational Therapeutic Approach to Modulate the Early and Late Steps of the Inflammatory Cascade in Polymicrobial Sepsis
Cecal ligation and puncture (CLP) is an experimental polymicrobial sepsis induced systemic inflammation that leads to acute organ failure. Aim of our study was to evaluate the effects of SP600125, a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, to modulate the early and late steps of the inf...
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| Udgivet i: | Mediators Inflamm |
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| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Hindawi Publishing Corporation
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4385695/ https://ncbi.nlm.nih.gov/pubmed/25873765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/591572 |
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