Efficacy Endpoints of RTOG 0247: A Randomized Phase II Study of Neoadjuvant Radiation Therapy Plus Concurrent Capecitabine and Irinotecan or Capecitabine and Oxaliplatin for Patients with Locally Advanced Rectal Cancer

PURPOSE/OBJECTIVES: Primary endpoint analysis of RTOG 0247 demonstrated preoperative RT with capecitabine plus oxaliplatin achieved a pCR pre-specified threshold (21%) to merit further study, whereas the RT with capecitabine plus irinotecan arm did not (10%). Secondary efficacy endpoints are reporte...

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Veröffentlicht in:Int J Radiat Oncol Biol Phys
Hauptverfasser: Wong, Stuart J., Moughan, J., Meropol, Neal J., Anne, Pramila Rani, Kachnic, Lisa A., Rashid, Asif, Watson, James C., Mitchell, Edith P., Pollock, Jondavid, Lee, R. Jeffrey, Haddock, Michael, Erickson, Beth A., Willett, Christopher G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385459/
https://ncbi.nlm.nih.gov/pubmed/25446610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2014.09.031
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