STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

Spontaneous T cell responses against tumors occur frequently and have prognostic value in patients. The mechanism of innate immune sensing of immunogenic tumors leading to adaptive T cell responses remains undefined, although type I interferons (IFNs) are implicated in this process. We found that sp...

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Dettagli Bibliografici
Pubblicato in:Immunity
Autori principali: Woo, Seng-Ryong, Fuertes, Mercedes B., Corrales, Leticia, Spranger, Stefani, Furdyna, Michael J., Leung, Michael Y.K., Duggan, Ryan, Wang, Ying, Barber, Glen N., Fitzgerald, Katherine A., Alegre, Maria-Luisa, Gajewski, Thomas F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384884/
https://ncbi.nlm.nih.gov/pubmed/25517615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.10.017
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