Noninvasive Molecular Imaging of Apoptosis in a Mouse Model of Anthracycline-Induced Cardiotoxicity

BACKGROUND: Anthracycline-induced cardiotoxicity and myocardial dysfunction may be associated with apoptosis. Caspase 3 catalyzes a terminal step in apoptosis, and its expression may serve as a marker of cardiomyocyte apoptosis. We synthesized 18F-CP18, a caspase-3 substrate and evaluated cardiac 18...

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Pubblicato in:Circ Cardiovasc Imaging
Autori principali: Su, Helen, Gorodny, Natalia, Gomez, Luis Felipe, Gangadharmath, Umesh, Mu, Fanrong, Chen, Gang, Walsh, Joseph C., Szardenings, Katrin, Kolb, Hartmuth C., Tamarappoo, Balaji
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384653/
https://ncbi.nlm.nih.gov/pubmed/25657296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCIMAGING.114.001952
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