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Rapid and accurate estimates of statistical significance for sequence data base searches.
A central question in sequence comparison is the statistical significance of an observed similarity. For local alignment containing gaps to optimize sequence similarity this problem has so far not been solved mathematically. Using as a basis the Chen-Stein theory of Poisson approximation, we present...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC43840/ https://ncbi.nlm.nih.gov/pubmed/8197109 |
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