Cleaved NOTCH1 expression pattern in head and neck squamous cell carcinoma is associated with NOTCH1 mutation, HPV status and high-risk features

The Notch pathway is frequently altered in HNSCCs, however the clinical significance of NOTCH1 dysregulation is poorly understood. This study was designed to characterize expression of the transcriptionally active NOTCH1 Intracellular Domain (NICD1) in HNSCCs and evaluate its association with NOTCH1...

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Vydáno v:Cancer Prev Res (Phila)
Hlavní autoři: Rettig, Eleni M, Chung, Christine H, Bishop, Justin A, Howard, Jason D, Sharma, Rajni, Li, Ryan J, Douville, Christopher, Karchin, Rachel, Izumchenko, Evgeny, Sidransky, David, Koch, Wayne, Califano, Joseph, Agrawal, Nishant, Fakhry, Carole
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383699/
https://ncbi.nlm.nih.gov/pubmed/25633867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-14-0366
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