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Cleaved NOTCH1 expression pattern in head and neck squamous cell carcinoma is associated with NOTCH1 mutation, HPV status and high-risk features

The Notch pathway is frequently altered in HNSCCs, however the clinical significance of NOTCH1 dysregulation is poorly understood. This study was designed to characterize expression of the transcriptionally active NOTCH1 Intracellular Domain (NICD1) in HNSCCs and evaluate its association with NOTCH1...

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Dettagli Bibliografici
Pubblicato in:Cancer Prev Res (Phila)
Autori principali: Rettig, Eleni M, Chung, Christine H, Bishop, Justin A, Howard, Jason D, Sharma, Rajni, Li, Ryan J, Douville, Christopher, Karchin, Rachel, Izumchenko, Evgeny, Sidransky, David, Koch, Wayne, Califano, Joseph, Agrawal, Nishant, Fakhry, Carole
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383699/
https://ncbi.nlm.nih.gov/pubmed/25633867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-14-0366
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