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Pharmacokinetics and Bioavailability of a Therapeutic Enzyme (Idursulfase) in Cynomolgus Monkeys after Intrathecal and Intravenous Administration

Intravenous enzyme replacement therapy with iduronate-2-sulfatase is an approved treatment for Hunter syndrome, however, conventional intravenous delivery cannot treat the neurologic manifestations of the disease due to its limited central nervous system penetration. Intrathecal administration of id...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Xie, Hongsheng, Chung, Jou-Ku, Mascelli, Mary Ann, McCauley, Thomas G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383552/
https://ncbi.nlm.nih.gov/pubmed/25836678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122453
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