Sample Preparation and Extraction in Small Sample Volumes Suitable for Pediatric Clinical Studies: Challenges, Advances, and Experiences of a Bioanalytical HPLC-MS/MS Method Validation Using Enalapril and Enalaprilat

In USA and Europe, medicines agencies force the development of child-appropriate medications and intend to increase the availability of information on the pediatric use. This asks for bioanalytical methods which are able to deal with small sample volumes as the trial-related blood lost is very restr...

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Publicat a:Int J Anal Chem
Autors principals: Burckhardt, Bjoern B., Laeer, Stephanie
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383429/
https://ncbi.nlm.nih.gov/pubmed/25873972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/796249
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