3T MR Spectroscopy Reveals an Imbalance between Excitatory and Inhibitory Neurotransmitters in Amyotrophic Lateral Sclerosis

OBJECTIVE: To determine whether there are reductions in γ-aminobutyric acid (GABA) and elevations of glutamate + glutamine (Glx) levels in different brain regions of patients with amyotrophic lateral sclerosis (ALS) using proton magnetic resonance spectroscopy ((1)H-MRS). DESIGN: 3T short echo time...

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Pubblicato in:JAMA Neurol
Autori principali: Foerster, Bradley R., Pomper, Martin G., Callaghan, Brian C., Petrou, Myria, Edden, Richard A.E., Mohamed, Mona A., Welsh, Robert C., Carlos, Ruth C., Barker, Peter B., Feldman, Eva L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382938/
https://ncbi.nlm.nih.gov/pubmed/23797905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2013.234
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