PAK6 increase chemoresistance and is a prognostic marker for stage II and III colon cancer patients undergoing 5-FU based chemotherapy

p21-Activated kinase 6 (PAK6) has been implicated in radiotherapy and docetaxel resistance. We have further evaluated PAK6 as a predictor of 5-fluorouracil (5-FU) treatment response in colon cancer. Here we report that in colon cancer PAK6 promotes tumor progression and chemoresistance both in vitro...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Chen, Jian, Lu, Huijun, Yan, Dongwang, Cui, Feifei, Wang, Xiaoliang, Yu, Fudong, Xue, Yingming, Feng, Xiaodong, Wang, Jingtao, Wang, Xiao, Jiang, Tao, Zhang, Meng, Zhao, Senlin, Yu, Yang, Tang, Huamei, Peng, Zhihai
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381600/
https://ncbi.nlm.nih.gov/pubmed/25426562
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