Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models

INTRODUCTION: Increased expression of αv integrins is frequently associated with tumor cell adhesion, migration, invasion and metastasis, and correlates with poor prognosis in breast cancer. However, the mechanism by which αv integrins can enhance breast cancer progression is still largely unclear....

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Udgivet i:Breast Cancer Res
Main Authors: Li, Yihao, Drabsch, Yvette, Pujuguet, Philippe, Ren, Jiang, van Laar, Theo, Zhang, Long, van Dam, Hans, Clément-Lacroix, Philippe, ten Dijke, Peter
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381510/
https://ncbi.nlm.nih.gov/pubmed/25849225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-015-0537-8
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