Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models

INTRODUCTION: Increased expression of αv integrins is frequently associated with tumor cell adhesion, migration, invasion and metastasis, and correlates with poor prognosis in breast cancer. However, the mechanism by which αv integrins can enhance breast cancer progression is still largely unclear....

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Publicado en:Breast Cancer Res
Autores principales: Li, Yihao, Drabsch, Yvette, Pujuguet, Philippe, Ren, Jiang, van Laar, Theo, Zhang, Long, van Dam, Hans, Clément-Lacroix, Philippe, ten Dijke, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381510/
https://ncbi.nlm.nih.gov/pubmed/25849225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-015-0537-8
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