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Vibrational entropy differences between mesophile and thermophile proteins and their use in protein engineering
We recently introduced ENCoM, an elastic network atomic contact model, as the first coarse-grained normal mode analysis method that accounts for the nature of amino acids and can predict the effect of mutations on thermostability based on changes vibrational entropy. In this proof-of-concept article...
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| Publicado en: | Protein Sci |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Blackwell Publishing Ltd
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4380979/ https://ncbi.nlm.nih.gov/pubmed/25367089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2592 |
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