A Mouse Model of Human Primitive Neuroectodermal Tumors Resulting from Microenvironmentally-Driven Malignant Transformation of Orthotopically Transplanted Radial Glial Cells

There is growing evidence and a consensus in the field that most pediatric brain tumors originate from stem cells, of which radial glial cells constitute a subtype. Here we show that orthotopic transplantation of human radial glial (RG) cells to the subventricular zone of the 3rd ventricle - but not...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Malchenko, Sergey, Sredni, Simone Treiger, Hashimoto, Hitoshi, Kasai, Atsushi, Nagayasu, Kazuki, Xie, Jianping, Margaryan, Naira V., Seiriki, Kaoru, Lulla, Rishi R., Seftor, Richard E. B., Pachman, Lauren M., Meltzer, Herbert Y., Hendrix, Mary J. C., Soares, Marcelo B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380339/
https://ncbi.nlm.nih.gov/pubmed/25826270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121707
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