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Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels

Cystic fibrosis transmembrane conductance regulator (CFTR) channel opening and closing are driven by cycles of adenosine triphosphate (ATP) binding–induced formation and hydrolysis-triggered disruption of a heterodimer of its cytoplasmic nucleotide-binding domains (NBDs). Although both composite sit...

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Vydáno v:J Gen Physiol
Hlavní autoři: Chaves, Luiz A. Poletto, Gadsby, David C.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380215/
https://ncbi.nlm.nih.gov/pubmed/25825169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201411347
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