Breast cancer-secreted miR-122 reprograms glucose metabolism in pre-metastatic niche to promote metastasis

Reprogrammed glucose metabolism as a result of increased glycolysis and glucose uptake is a hallmark of cancer. Here we show that cancer cells can suppress glucose uptake by non-tumour cells in the pre-metastatic niche, by secreting vesicles that carry high levels of the miR-122 microRNA. High miR-1...

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Publicat a:Nat Cell Biol
Autors principals: Fong, Miranda Y., Zhou, Weiying, Liu, Liang, Alontaga, Aileen Y., Chandra, Manasa, Ashby, Jonathan, Chow, Amy, O’Connor, Sean Timothy Francis, Li, Shasha, Chin, Andrew R., Somlo, George, Palomares, Melanie, Li, Zhuo, Tremblay, Jacob R., Tsuyada, Akihiro, Sun, Guoqiang, Reid, Michael A., Wu, Xiwei, Swiderski, Piotr, Ren, Xiubao, Shi, Yanhong, Kong, Mei, Zhong, Wenwan, Chen, Yuan, Wang, Shizhen Emily
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380143/
https://ncbi.nlm.nih.gov/pubmed/25621950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3094
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