Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
The immunosuppressant rapamycin blocks p70s6k/p85s6k activation and phosphorylation of 40S ribosomal protein S6 in Swiss 3T3 cells. The same net result is obtained when the macrolide is added 3 hr after serum stimulation. In stimulated cells p70s6k/p85s6k inactivation is achieved within minutes, whe...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43801/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8183928/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.10.4441 |
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